nod mice การใช้

• NOD mice have polymorphisms in the Idd3 locus which are linked to IL-2 production.
• Loss of IL-2 can thereby contribute to the development of autoimmunity in NOD mice.
• NOD mice have a mutation in exon 2 of the CTLA-4 gene, which causes it to be spliced incorrectly.
• In 1993 a research article demonstrated that islet isografts were being transplanted into young diabetic mice [ STZ induced diabetic NOD mice ] and the mice survived at least about 22 days post transplantation.
• Prior to entering human clinical trials, Faustman's approach was tested in non-obese diabetic mice ( NOD mice ), a strain of mice that spontaneously develops beta islet cells to regenerate.
• In animal models of Diabetes mellitus ( NOD mice ), GM-CSF induces resistance by increasing the frequency of regulatory T cells which can suppress T cell proliferation through their T-cell receptors.
• NOD mice are also susceptible to developing other autoimmune syndromes, including autoimmunine sialitis, autoimmune thyroiditis, autoimmune peripheral polyneuropathy etc . Diabetes in these mice can be prevented by a single injection of mycobacterial adjuvants such as complete Freund's adjuvant ( FCA ) or Bacille de Calmette et Gu閞in or BCG vaccine.